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Autoimmune regulator regulates autophagy in THP-1 human monocytes

Liang SHI, Li-Hua HU, Yi-Rong LI

Frontiers of Medicine 2010, Volume 4, Issue 3, Pages 336-341 doi: 10.1007/s11684-010-0096-4

Abstract: However, the role of AIRE in autophagy in immune cells, especially in monocytes, is obscure.In the present study, we found that overexpression of AIRE in THP-1 human monocytes resulted in increasedOur findings indicate that AIRE plays a role in the regulation of autophagy in THP-1 human monocytes.

Keywords： autoimmune regulator autophagy monocytes light chain 3 (LC3)

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Identification of Monocytes Associated with Severe COVID-19 in the PBMCs of Severely Infected Patients Article

Yan Zhang, Shuting Wang, He Xia, Jing Guo, Kangxin He, Chenjie Huang, Rui Luo, Yanfei Chen, Kaijin Xu, Hainv Gao, Jifang Sheng, Lanjuan Li

Engineering 2022, Volume 17, Issue 10, Pages 161-169 doi: 10.1016/j.eng.2021.05.009

Abstract:

Understanding the immunological characteristics of monocytes—including the characteristics associatedWe found that the monocytes were strongly remodeled in the severely/critically ill patients with COVID-19, with an increased proportion of monocytes and seriously reduced diversity.

Keywords： COVID-19 Severe infection Critically ill Monocytes Fibrosis